Acral lentiginous nevus

Definition:

The identification of this benign acral naevus is important in order to avoid misdiagnoses and consequent under- or over-treatment of doubtful pigmented lesions of acral skin.

Diagnosis:

The main morphological features distinguishing the acral-lentiginous naevi from other acral non-lentiginous naevi are: elongation of rete ridges, continuous proliferation of melanocytes at the dermo-epidermal junction, presence of single scattered melanocytes, or less commonly small clusters, within the upper epidermis, poor or absent lateral circumscription, melanocytes with abundant pale cytoplasm and round to oval, sometimes hyperchromatic, nuclei and prominent nucleoli present at the dermo-epidermal junction. Some histological features of acral-lentiginous naevi are similar to those of dysplastic naevi: however, anastomosing rete ridges, cytological atypia and well-formed lamellar fibroplasia are absent.

References:

Clemente C, Zurrida S, Bartoli C, Bono A, Collini P, Rilke F. Acral-lentiginous naevus of plantar skin. Histopathology. 1995 Dec;27(6):549-55.
Han KH et al. Acral lentiginous nevus. J Dermatol. 1998 Jan;25(1):23-7.

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